A multi-stakeholder effort to develop innovative stroke treatments

The COllaboration for New TReatments of Acute Stroke (CONTRAST) consortium aims to improve the outcome of patients with a stroke. It builds on the previous and successful MR CLEAN trial. CONTRAST merges translational research and pragmatic randomized clinical trials. The consortium partners will perform five large acute stroke trials to test novel treatment strategies. This is complemented by a preclinical program, the development of a large biobank, and the identification of challenges for the organization and logistics of the acute stroke care network.

icon_Money € 14 M


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In the Netherlands alone, 9000 people die each year from a stroke. Many more people survive a stroke, but have to live with consequences such as (partial) paralysis and speech impairment. In 2017, seven Dutch research institutes, one French research institute, and industrial partner Stryker, established the CONTRAST consortium. Working closely with patient organisations, the goal of this multi-stakeholder effort is to develop innovative stroke treatments. Five clinical trials and translational research will help to improve patient outcomes and decrease the burden for those who survive a stroke. Visit the CONTRAST website for more information.

Supporting the consortium organisation

CONTRAST brings together clinical and translational scientists from all academic and large clinical centers. Lygature has supported the organisation of the consortium, and its main task is program management:

  • Program management. Lygature is responsible for management support at consortium level. Activities include, amongst others, planning, organizing consortium meetings, reporting, and internal communications.

* Image courtesy of Stryker Neurovascular  |  Image Copyright © 2015 Stryker - NV00015919.AA

Lygature together with

Project updates

  • The CONTRAST Young Talent Program (YTP) open for applications

    The CONTRAST Young Talent Program (YTP) aims to stimulate and support young researchers in developing and evaluating high quality innovative scientific ideas across the entire range of stroke research, both in the clinical and/or population-based setting and in preclinical research. The CONTRAST consortium offers young talents the opportunity to apply for a voucher of 50,000 euro.
    Deadline for submission is Friday June 22, 2018.

    Read more

  • CONTRAST Workshop on acute stroke management and translational research

    The next CONTRAST Workshop will be held on May 23,2018  in AMC, Amsterdam. The exciting program features updates on acute stroke management and translational research by the WP coordinators, and three guest speakers: prof Gert Kwakkel (VUmc Amsterdam), prof Denis Vivien (Caen University and Medical School, France) and prof Pengfei Yang  (Shanghai Hospital, Shanghai China). More information can be found here.